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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Antinociceptive efficacy of lacosamide in the monosodium iodoacetate rat model for osteoarthritis pain

Figure 1

Histological analysis of synovial tissue and articular cartilage pre- and post-monosodium iodoacetate (MIA) injection. Time course of histological changes of the rat knee before and days 3 and 14 after MIA injection. Left sections of the medial aspect of rat knee joints were stained with hematoxylin and eosin, right sections with safranin-O fast green. In non-arthritic rats no abnormality is present. On day 3 after MIA treatment the hematoxylin and eosin stained sections show significant expansion of the synovial membrane with a large amount of cellular infiltrate. No inflammation can be seen on day 14 post-MIA injection. The sections stained with safranin-O fast green reflect major cartilage degeneration on day 14 post-MIA injection. SM, synovial membrane; FE, femur; TI, tibia.

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Arthritis Research & Therapy

ISSN: 1478-6362

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