Comparison of pneumonitis and sialadenitis in Treg cell- and CCR2-Treg cell-transferred MRL/lpr mice. Representative photographs are shown. Treg and CCR2-Treg cells were transferred via retro-orbital injection in 12-week-old MRL/lpr mice. One hundred thousand or 5 × 105 cells were injected into mice twice every 2 weeks, and the pathological changes were evaluated 3 weeks after the last injection (that is, when the mice were 17 weeks old). Non-treated 17-week-old MRL/lpr mice were used as control. CCR2-Treg cell, CD4+CD25+Foxp3+ CCR2-transfected T cell; HE, hematoxylin and eosin; MRL/lpr, MRL/MpJ-lpr/lpr; Treg cell, CD4+CD25+Foxp3+ T cell.