Cells of the synovium in rheumatoid arthritis. B cells

Table 1 Potential targets driving B cell accumulation in the synovium

Target	Function
CXCL12 (SDF-1)	B cell and plasma cell chemoattractant
CXCL13	B cell chemoattractant
Lymphotoxin-β	Organization of B cells within lymphoid architecture
	Induction of CXCL13
IL-5, IL-6, TNF-α	Promote plasma cell accumulation and survival
BAFF	Immature and mature B cell survival and proliferation
APRIL	Mature B cell and plasma cell survival
TNF-α and IFN-γ	Induces B cell release from bone marrow
	Increased production of BAFF and APRIL

APRIL, a proliferation-inducing ligand; BAFF, B cell-activating factor of the TNF family; CXCL, CXC chemokine ligand; IFN, interferon; IL, interleukin; TNF, tumour necrosis factor.

ISSN: 1478-6362