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Table 1 Potential targets driving B cell accumulation in the synovium

From: Cells of the synovium in rheumatoid arthritis. B cells

Target Function
CXCL12 (SDF-1) B cell and plasma cell chemoattractant
CXCL13 B cell chemoattractant
Lymphotoxin-β Organization of B cells within lymphoid architecture
  Induction of CXCL13
IL-5, IL-6, TNF-α Promote plasma cell accumulation and survival
BAFF Immature and mature B cell survival and proliferation
APRIL Mature B cell and plasma cell survival
TNF-α and IFN-γ Induces B cell release from bone marrow
  Increased production of BAFF and APRIL
  1. APRIL, a proliferation-inducing ligand; BAFF, B cell-activating factor of the TNF family; CXCL, CXC chemokine ligand; IFN, interferon; IL, interleukin; TNF, tumour necrosis factor.