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Table 3 Relationship between HLA-DRB1 allele carrier status and anticitrullinated protein/peptide autoantibody status in French patients with early rheumatoid arthritis

From: A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis

  Carrier status Odds ratio (95% confidence interval) P P for trend
  Yes No    
S1 carrier      
   CCP2-positive 32 (57.1) 78 (75.0) 0.44 (0.21–0.94) 0.0312 0.0134
   CCP2-negative 24 (42.9) 26 (25.0)    
   AhFibA-positive 31 (55.4) 77 (74.0) 0.43 (0.21–0.91) 0.0213 0.0113
   AhFibA-negative 25 (44.6) 27 (26.0)    
   CCP2-positive      
   CCP2-negative 49 (83.1) 61 (60.4) 3.21 (1.39–7.9) 0.0028* 0.0049*
   AhFibA-positive 10 (16.9) 40 (39.6)    
   AhFibA-negative 50 (84.8) 58 (57.4) 4.12 (1.75–10.49) 0.0004* 0.0003*
   CCP2-positive 9 (15.2) 43 (42.6)    
S3P carrier      
   CCP2-positive 61 (79.2) 49 (59.0) 2.65 (1.24–5.74) 0.0066* 0.0014*
   CCP2-negative 16 (20.8) 34 (41.0)    
   AhFibA-positive 61 (79.2) 47 (56.6) 2.92 (1.38–6.32) 0.0025* 0.0035*
   AhFibA-negative 16 (20.8) 36 (43.4)    
S3D carrier      
   CCP2-positive 17 (45.9) 93 (75.6) 0.27 (0.12–0.63) 0.0011* 0.0009*
   CCP2-negative 20 (54.1) 30 (24.4)    
   AhFibA-positive 19 (51.4) 89 (72.4) 0.4 (0.18–0.93) 0.0266 0.0145
   AhFibA-negative 18 (48.6) 34 (27.6)    
  1. Data presented as n (%). Status for anticyclic citrullinated peptides (anti-CCP2) antibodies or antideiminated human fibrinogen autoantibodies (AhFibA) among 160 patients with early rheumatoid arthritis, carrying the different HLA-DRB1 alleles encoding the shared epitope classified into four groups according to the new classification. Odds ratios, 95% alpha-risk confidence interval and P value for exact Fisher test. The dose effect was investigated for alleles positively or negatively associated with immunological markers using tests for trend of the log odds. *Significant after correcting for multiple testing according to the Benjamini–Yekutieli 2001 method at an overall critical P value of 5%.