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Table 3 Clinical characteristics and diplotype configurations at the NAT2 gene in five patients who experienced severe adverse events with co-trimoxazole

From: Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus

Patient number Age (years)/sex Diplotype configuration Acetylator phenotype Adverse events
1 52/female NAT2*6A/*6A Slow TEN, liver dysfunction
2 56/female NAT2*5B/*7B Slow SJS, liver dysfunction
3 43/female NAT2*6A/*7B Slow Thrombocytopenia, liver dysfunction
4 48/female NAT2*4/*7B Fast Thrombocytopenia
5 46/female NAT2*4/*6A Fast SJS, liver dysfunction
  1. NAT2, N-acetyltransferase 2; SJS, Stevens-Johnson syndrome; TEN, toxic epidermal necrolysis.