Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus

Table 3 Clinical characteristics and diplotype configurations at the NAT2 gene in five patients who experienced severe adverse events with co-trimoxazole

Patient number	Age (years)/sex	Diplotype configuration	Acetylator phenotype	Adverse events
1	52/female	NAT26A/6A	Slow	TEN, liver dysfunction
2	56/female	NAT25B/7B	Slow	SJS, liver dysfunction
3	43/female	NAT26A/7B	Slow	Thrombocytopenia, liver dysfunction
4	48/female	NAT24/7B	Fast	Thrombocytopenia
5	46/female	NAT24/6A	Fast	SJS, liver dysfunction

NAT2, N-acetyltransferase 2; SJS, Stevens-Johnson syndrome; TEN, toxic epidermal necrolysis.

ISSN: 1478-6362