Table 1 Clinical summary of the 10 patients studied and their response to treatment
From: A pilot study of IL-1 inhibition by anakinra in acute gout
Patient | Clinical presentation | Affected joints | Serum uric acid (normal range, 160–390 μmol/l) | Serum creatinine (normal range, 44–80 μmol/l) | Hypouricemic treatment | Effect of anakinra (hours) | Patient assessment of improvement in pain (%) |
|---|---|---|---|---|---|---|---|
Case 1 (female, 72 years old) | Chronic tophaceous gout, renal stones | Fingers, toes | 637 | 79 | Uricase | 36 | 70 |
Case 2 (male, 70 years old) | Chronic tophaceous gout | Ankle, toes | 564 | 202 | Allopurinol | 24 | 90 |
Case 3 (male, 72 years old) | Acute gout | Knee, ankle, foot | 482 | 121 | Allopurinol | 24 | 90 |
Case 4 (male, 51 years old) | Acute gout | Ankle, toe | 396 | 84 | Allopurinol | 24 | 100 |
Case 5 (male, 40 years old) | Acute gout | Ankle, toe | 322 | 113 | Allopurinol | 36 | 100 |
Case 6 (female, 72 years old) | Acute gout | Feet, toe | 572 | 72 | None | 36 | 80 |
Case 7 (male, 76 years old) | Acute gout | Ankle, foot | 338 | 79 | None | 36 | 100 |
Case 8 (male, 70 years old) | Acute gout | Wrist, elbow, hand | 779 | 406 | None | 48 | 50 |
Case 9 (male, 53 years old) | Chronic tophaceous gout | Elbow, finger, foot, ankle | 660 | 84 | Allopurinol | 48 | 50 |
Case 10 (male, 38 years old) | Acute gout | Wrist, finger | 540 | 84 | None | 24 | 60 |