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Table 1 Allele/haplotype distribution of IRF5 polymorphisms in Korean SLE patients/controls and association analysis for SLE

From: Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population

Loci Associated allele Cases Controls OR (95% CI) χ2 P a
   (n = 593) (n = 972)    
rs729302 (A > C) A 0.729 0.680 1.27 (1.08–1.49) 8.44 0.0037
rs2004640 (G > T) T 0.385 0.321 1.32 (1.14–1.54) 13.22 0.0003
rs752637 (T > C) C 0.455 0.398 1.27 (1.09–1.47) 9.73 0.0018
rs2280714 (T > C) T 0.395 0.402 0.97 (0.84–1.13) 0.15 0.6971
Haplotypeb AGTC 0.355 0.368 0.95 (0.82–1.11) 0.49 0.4840
  ATCT 0.352 0.295 1.28 (0.10–1.50) 10.85 0.001
  CGTT 0.158 0.205 0.74 (0.61–0.89) 10.21 0.0014
  CGCT 0.066 0.071 0.96 (0.72–1.28) 0.34 0.5600
  CGTC 0.034 0.024 0.97 (0.63–1.50) 0.78 0.3784
  CTCT 0.016 0.017 1.23 (0.72–2.09) 0.07 0.7919
Haplotypec T–T 0.380 0.311 1.36 (1.16–1.58) 15.2 9.64 × 10-5
  G–T 0.225 0.283 0.74 (0.62–0.87) 12.5 0.0004
  G–C 0.387 0.398 0.95 (0.82–1.11) 0.4 0.5330
  T–T 0.008 0.008 0.96 (0.42–2.21) 0.0 0.9323
  1. Case-control analysis. χ2 analyses were used to evaluate the significance of differences in genotype and allele frequencies in the case-control samples. The allele frequencies for cases and controls were used to calculate the OR and the 95% CI. For the case-control haplotype analysis, Haploview v3.2 (Broad Institute of Harvard and MIT Cambridge, MA, USA) was used to generate haplotype frequencies and calculate the significance of associations. CI, confidence interval; IRF5, IFN regulatory factor 5; OR, odds ratio; SLE, systemic lupus erythematosus.
  2. aP value, uncorrected for multiple tests.
  3. bHaplotype consisting of markers rs729302 (A > C), rs2004640 (G > T), rs752637 (T > C) and rs2280714 (T > C).
  4. cHaplotype consisting of markers rs2004640 (G > T) and rs2280714 (T > C).