| | |
n
|
No. of T alleles
|
Frequency of T alleles
|
No. of G alleles
|
Frequency of G alleles
|
OR (95% CI)
|
P
a
|
Pooled ORb
|
Pooled Pb
|
|---|
|
Korea
|
Cases
|
589
|
454
|
0.385
|
724
|
0.615
|
1.32 (1.14–1.54)
|
0.0003
| | |
| |
Controls
|
950
|
610
|
0.321
|
1290
|
0.679
| | | | |
|
Argentinac
|
Cases
|
284
|
309
|
0.54
|
259
|
0.46
|
1.52 (1.20–1.93)
|
0.00035
| | |
| |
Controls
|
279
|
245
|
0.44
|
313
|
0.56
| | | | |
|
Spainc
|
Cases
|
444
|
559
|
0.63
|
329
|
0.37
|
1.42 (1.18–1.71)
|
0.00016
| | |
| |
Controls
|
541
|
589
|
0.54
|
493
|
0.46
| | | | |
| | | | | | | | | |
1.45 (1.32–1.58)
|
4.4 × 10-16
|
|
Sweden-1c
|
Cases
|
208
|
260
|
0.63
|
156
|
0.38
|
1.31 (1.01–1.71)
|
0.04268
| | |
| |
Controls
|
254
|
284
|
0.56
|
224
|
0.44
| | | | |
|
USAc
|
Cases
|
725
|
879
|
0.61
|
571
|
0.39
|
1.47 (1.29–1.67)
|
3.6 × 10-9
| | |
| |
Controls
|
1,434
|
1,467
|
0.51
|
1401
|
0.49
| | | | |
|
Sweden-2d
|
Cases
|
480
|
595
|
0.62
|
365
|
0.38
|
1.51 (1.21–1.87)
|
0.0002
| | |
| |
Controls
|
256
|
266
|
0.52
|
246
|
0.48
| | | | |
| | | | | | | | | |
1.59 (1.31–1.94)
|
7.1 × 10-7
|
|
Finlandd
|
Cases
|
109
|
137
|
0.63
|
81
|
0.37
|
1.84 (1.27–2.66)
|
0.00133
| | |
| |
Controls
|
121
|
116
|
0.48
|
126
|
0.52
| | | | |
|
Combined analysis
|
Cases
|
2,839
|
3,193
|
0.56
|
2,485
|
0.44
| | |
1.44 (1.34–1.55)
|
1.85 × 10-23
|
| |
Controls
|
3,835
|
3,577
|
0.47
|
4,093
|
0.53
| | | | |
- Meta-analysis. Mantel–Haenszel meta-analysis of the ORs; these data were subsequently combined in a separate analysis with the published results of the association of rs2004640 (G > T) with SLE from previous studies [1,2]. The Breslow–Day test for heterogeneity was not significant for allele distributions (P = 0.7115, data not shown), suggesting the homogeneity of studies. 'Number of alleles' refers to number of alleles of rs2004640 (G > T). CI, confidence interval; IRF5, IFN regulatory factor 5; OR, odds ratio; SLE, systemic lupus erythematosus.
- aχ2 tests were used to evaluate the significance of differences in allele frequencies in the case-control samples.
- bMantel–Haenszel test [12] of pooled ORs and 95% CIs.
- cData from Graham and co-workers [1].
- dData from Sigurdsson and co-workers [2].
