Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population

Table 2 Case-control association analysis of the IRF5 rs2004640 (G > T) T allele with SLE

		n	No. of T alleles	Frequency of T alleles	No. of G alleles	Frequency of G alleles	OR (95% CI)	P ^a	Pooled OR^b	Pooled P^b
Korea	Cases	589	454	0.385	724	0.615	1.32 (1.14–1.54)	0.0003
	Controls	950	610	0.321	1290	0.679
Argentina^c	Cases	284	309	0.54	259	0.46	1.52 (1.20–1.93)	0.00035
	Controls	279	245	0.44	313	0.56
Spain^c	Cases	444	559	0.63	329	0.37	1.42 (1.18–1.71)	0.00016
	Controls	541	589	0.54	493	0.46
									1.45 (1.32–1.58)	4.4 × 10^-16
Sweden-1^c	Cases	208	260	0.63	156	0.38	1.31 (1.01–1.71)	0.04268
	Controls	254	284	0.56	224	0.44
USA^c	Cases	725	879	0.61	571	0.39	1.47 (1.29–1.67)	3.6 × 10^-9
	Controls	1,434	1,467	0.51	1401	0.49
Sweden-2^d	Cases	480	595	0.62	365	0.38	1.51 (1.21–1.87)	0.0002
	Controls	256	266	0.52	246	0.48
									1.59 (1.31–1.94)	7.1 × 10^-7
Finland^d	Cases	109	137	0.63	81	0.37	1.84 (1.27–2.66)	0.00133
	Controls	121	116	0.48	126	0.52
Combined analysis	Cases	2,839	3,193	0.56	2,485	0.44			1.44 (1.34–1.55)	1.85 × 10^-23
	Controls	3,835	3,577	0.47	4,093	0.53

Meta-analysis. Mantel–Haenszel meta-analysis of the ORs; these data were subsequently combined in a separate analysis with the published results of the association of rs2004640 (G > T) with SLE from previous studies [1,2]. The Breslow–Day test for heterogeneity was not significant for allele distributions (P = 0.7115, data not shown), suggesting the homogeneity of studies. 'Number of alleles' refers to number of alleles of rs2004640 (G > T). CI, confidence interval; IRF5, IFN regulatory factor 5; OR, odds ratio; SLE, systemic lupus erythematosus.
^aχ² tests were used to evaluate the significance of differences in allele frequencies in the case-control samples.
^bMantel–Haenszel test [12] of pooled ORs and 95% CIs.
^cData from Graham and co-workers [1].
^dData from Sigurdsson and co-workers [2].

ISSN: 1478-6362