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Table 2 Case-control association analysis of the IRF5 rs2004640 (G > T) T allele with SLE

From: Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population

  

n

No. of T alleles

Frequency of T alleles

No. of G alleles

Frequency of G alleles

OR (95% CI)

P a

Pooled ORb

Pooled Pb

Korea

Cases

589

454

0.385

724

0.615

1.32 (1.14–1.54)

0.0003

  
 

Controls

950

610

0.321

1290

0.679

    

Argentinac

Cases

284

309

0.54

259

0.46

1.52 (1.20–1.93)

0.00035

  
 

Controls

279

245

0.44

313

0.56

    

Spainc

Cases

444

559

0.63

329

0.37

1.42 (1.18–1.71)

0.00016

  
 

Controls

541

589

0.54

493

0.46

    
         

1.45 (1.32–1.58)

4.4 × 10-16

Sweden-1c

Cases

208

260

0.63

156

0.38

1.31 (1.01–1.71)

0.04268

  
 

Controls

254

284

0.56

224

0.44

    

USAc

Cases

725

879

0.61

571

0.39

1.47 (1.29–1.67)

3.6 × 10-9

  
 

Controls

1,434

1,467

0.51

1401

0.49

    

Sweden-2d

Cases

480

595

0.62

365

0.38

1.51 (1.21–1.87)

0.0002

  
 

Controls

256

266

0.52

246

0.48

    
         

1.59 (1.31–1.94)

7.1 × 10-7

Finlandd

Cases

109

137

0.63

81

0.37

1.84 (1.27–2.66)

0.00133

  
 

Controls

121

116

0.48

126

0.52

    

Combined analysis

Cases

2,839

3,193

0.56

2,485

0.44

  

1.44 (1.34–1.55)

1.85 × 10-23

 

Controls

3,835

3,577

0.47

4,093

0.53

    
  1. Meta-analysis. Mantel–Haenszel meta-analysis of the ORs; these data were subsequently combined in a separate analysis with the published results of the association of rs2004640 (G > T) with SLE from previous studies [1,2]. The Breslow–Day test for heterogeneity was not significant for allele distributions (P = 0.7115, data not shown), suggesting the homogeneity of studies. 'Number of alleles' refers to number of alleles of rs2004640 (G > T). CI, confidence interval; IRF5, IFN regulatory factor 5; OR, odds ratio; SLE, systemic lupus erythematosus.
  2. aχ2 tests were used to evaluate the significance of differences in allele frequencies in the case-control samples.
  3. bMantel–Haenszel test [12] of pooled ORs and 95% CIs.
  4. cData from Graham and co-workers [1].
  5. dData from Sigurdsson and co-workers [2].