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Table 2 Case-control association analysis of the IRF5 rs2004640 (G > T) T allele with SLE

From: Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population

   n No. of T alleles Frequency of T alleles No. of G alleles Frequency of G alleles OR (95% CI) P a Pooled ORb Pooled Pb
Korea Cases 589 454 0.385 724 0.615 1.32 (1.14–1.54) 0.0003   
  Controls 950 610 0.321 1290 0.679     
Argentinac Cases 284 309 0.54 259 0.46 1.52 (1.20–1.93) 0.00035   
  Controls 279 245 0.44 313 0.56     
Spainc Cases 444 559 0.63 329 0.37 1.42 (1.18–1.71) 0.00016   
  Controls 541 589 0.54 493 0.46     
          1.45 (1.32–1.58) 4.4 × 10-16
Sweden-1c Cases 208 260 0.63 156 0.38 1.31 (1.01–1.71) 0.04268   
  Controls 254 284 0.56 224 0.44     
USAc Cases 725 879 0.61 571 0.39 1.47 (1.29–1.67) 3.6 × 10-9   
  Controls 1,434 1,467 0.51 1401 0.49     
Sweden-2d Cases 480 595 0.62 365 0.38 1.51 (1.21–1.87) 0.0002   
  Controls 256 266 0.52 246 0.48     
          1.59 (1.31–1.94) 7.1 × 10-7
Finlandd Cases 109 137 0.63 81 0.37 1.84 (1.27–2.66) 0.00133   
  Controls 121 116 0.48 126 0.52     
Combined analysis Cases 2,839 3,193 0.56 2,485 0.44    1.44 (1.34–1.55) 1.85 × 10-23
  Controls 3,835 3,577 0.47 4,093 0.53     
  1. Meta-analysis. Mantel–Haenszel meta-analysis of the ORs; these data were subsequently combined in a separate analysis with the published results of the association of rs2004640 (G > T) with SLE from previous studies [1,2]. The Breslow–Day test for heterogeneity was not significant for allele distributions (P = 0.7115, data not shown), suggesting the homogeneity of studies. 'Number of alleles' refers to number of alleles of rs2004640 (G > T). CI, confidence interval; IRF5, IFN regulatory factor 5; OR, odds ratio; SLE, systemic lupus erythematosus.
  2. aχ2 tests were used to evaluate the significance of differences in allele frequencies in the case-control samples.
  3. bMantel–Haenszel test [12] of pooled ORs and 95% CIs.
  4. cData from Graham and co-workers [1].
  5. dData from Sigurdsson and co-workers [2].