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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Morphological characterization of intra-articular HMGB1 expression during the course of collagen-induced arthritis

Figure 2

High-mobility group chromosomal box protein 1 (HMGB1) expression at different time points after immunization. Representative micrographs illustrating immunohistochemical staining of HMGB1. (a) In the non-proliferative synovial membrane of an unimmunized animal, a nuclear HMGB1 deposition is evident. (b) In addition to the nuclear expression, cytoplasmic HMGB1 staining appears in a large portion of cells in the synovial membrane 10 days after immunization, a time point preceding the expected clinical disease onset by 5 days. (c) An arthritic lesion, 28 days after immunization, in which an additional extracellular presence of HMGB1 is indicated by a brownish extracellular immunoreactivity surrounding cells displaying cytoplasmic HMGB1 staining. Original magnification ×500.

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