Skip to main content

Table 2 Significant differentially abundant proteins identified

From: High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis

GI#

Protein description

Upregulated in

Specificity

Sensitivity

P value (Fisher's exact, two sided)

4885165

Cystatin A (stefin A)

Control

0.650

1.000

1.92 × e-08

6995994

Aggrecan 1 (chondroitin sulfate proteoglycan 1)

Control

0.650

0.974

2.30 × e-07

1651921

Dermcidin

Control

0.600

1.000

1.13 × e-07

4502027

Albumin

OA

0.950

0.718

7.96 × e-07

4502067

α1-Microglobulin/bikunin precursor

OA

0.950

0.718

7.96 × e-07

4503689

Fibrinogen, α chain isoform α-E preprotein

OA

0.950

0.718

7.96 × e-07

4503715

Fibrinogen, γ chain isoform γ-A precursor

OA

1.000

0.744

1.43 × e-08

4557225

α2-Macroglobulin

OA

0.950

0.718

7.96 × e-07

4557325

Apolipoprotein E

OA

1.000

0.744

1.43 × e-08

4557327

Apolipoprotein H (β2-glycoprotein I)

OA

1.000

0.744

1.43 × e-08

4557385

Complement component 3 (gel slice 3)

OA

0.950

0.718

7.96 × e-07

4557385

Complement component 3 (gel slice 5)

OA

1.000

0.744

1.43 × e-08

4557485

Ceruloplasmin (ferroxidase)

OA

0.950

0.718

7.96 × e-07

4826762

Haptoglobin

OA

0.950

0.718

7.96 × e-07

9257232

Orosomucoid 1

OA

0.850

0.667

2.51 × e-04

32483410

Group specific component (vitamin D binding protein)

OA

1.000

0.744

1.43 × e-08

50345296

Complement component 4B preprotein (NP_001002029)

OA

1.000

0.744

1.43 × e-08

5147611

PREDICTED: similar to apolipoprotein A-1 precursor (apo-A-1; XP_496536)

OA

0.950

0.718

7.96 × e-07

55743122

Retinol-binding protein 4, plasma precursor (NP_006735)

OA

0.900

0.692

1.87 × e-05

  1. Eighteen proteins that were significantly differentially abundant (protein area) across control (n = 20) and OA (n = 39) groups by Wilcoxon's ranksum test at P < 1 × e-06. Sensitivity/specificity for each protein are calculated with respect to the number of samples of each group having protein area above or below the median area across all samples. The significance of median area dichotomy and true group label is assessed by two-sided Fisher's exact test. GI#, GenInfo accession.