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Table 3 Association of tumor necrosis factor-alpha gene promoter polymorphisms with rheumatoid arthritis activity and outcome measures

From: Contribution for new genetic markers of rheumatoid arthritis activity and severity: sequencing of the tumor necrosis factor-alpha gene promoter

  

DAS28a

HAQ

Systemic manifestations

Work disability

Joint surgery

RFb

SvdH score

  

Coeff

P value

Coeff

P value

Coeff

P value

Coeff

P value

Coeff

P value

Coeff

P value

Coeff

P value

<2 years

1036TT

1.111

0.280

0.367

0.505

-

-

-

-

-

-

    
 

863CC

-1.911

0.081

-0.799

0.178

-

-

-

-

-

-

    
 

857CC

-1.150

0.116

-0.200

0.614

-

-

-

-

-

-

    
 

308GG

0.154

0.827

0.357

0.480

-

-

-

-

-

-

    
 

238GG

-0.646

0.507

-0.878

0.148

-

-

-

-

-

-

    

2 to 10 years

1036TT

-0.071

0.912

-0.152

0.639

-0.482

0.690

-0.946

0.351

0.965

0.480

    
 

863CC

-0.286

0.661

0.147

0.659

0.050

0.970

0.686

0.514

-1.992

0.160

    
 

857CC

-0.289

0.314

0.074

0.620

-0.384

0.480

-0.773

0.093

-0.829

0.190

    
 

308GG

-0.507

0.080

0.133

0.395

-0.380

0.510

-1.133

0.027

0.255

0.770

    
 

238GG

-0.106

0.875

0.670

0.052

0.497

0.710

-0.917

0.415

-0.598

0.680

    

>10 years

1036TT

-0.023

0.966

-0.450

0.187

-0.704

0.417

-0.642

0.458

-1.481

0.133

    
 

863CC

-0.037

0.944

0.548

0.099

0.359

0.663

1.253

0.136

1.512

0.117

    
 

857CC

-0.002

0.996

0.036

0.834

-0.860

0.049

0.076

0.873

-1.217

0.006

    
 

308GG

-0.151

0.563

0.041

0.800

-0.337

0.427

1.736

0.002

0.496

0.257

    
 

238GG

-0.029

0.953

0.268

0.378

-1.308

0.099

0.525

0.522

1.088

0.253

    
 

1036TT

          

-0.422

0.512

  
 

863CC

          

1.142

0.072

  
 

857CC

          

0.559

0.079

  
 

308GG

          

0.015

0.964

  
 

238GG

          

1.089

0.062

  

<10 years

1036TT

            

-0.103

0.676

 

863CC

            

-0.062

0.809

 

857CC

            

-0.110

0.375

 

308GG

            

-0.299

0.039

 

238GG

            

-0.315

0.255

>10 years

1036TT

            

-0.003

0.992

 

863CC

            

0.222

0.405

 

857CC

            

-0.129

0.320

 

308GG

            

0.041

0.731

 

238GG

            

0.481

0.070

  1. Coefficients were adjusted for gender, education, disease-modifying anti-rheumatic drugs, prednisolone dose, use of biologics, family history, and hemoglobin. aModel was not adjusted for hemoglobin; banalysis was not stratified for disease duration. Coeff, coefficients; DAS28, disease activity score using 28 joint counts; HAQ, Health Assessment Questionnaire; RF, rheumatoid factor; SvdH, Sharp/van der Heijde.
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Arthritis Research & Therapy

ISSN: 1478-6362

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