Table 4 Association of tumor necrosis factor-alpha gene promoter haplotypes with rheumatoid arthritis activity and outcome measures
HAQ | DAS28 | Systemic manifestation | SvdH score | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<1 | >1 | <2.6 | 2.6–5.1 | >5.1 | No | Yes | |||||||
<2 years | CACAG | 1 | 0 | CACGG | 3 | 6 | 5 | CACAG | 1 | 0 | |||
CACGG | 7 | 8 | CCCGA | 1 | 1 | 0 | CACGG | 13 | 1 | ||||
CCCGA | 1 | 2 | TCCAG | 1 | 1 | 1 | CCCGA | 2 | 0 | ||||
TCCAG | 1 | 1 | TCCGG | 9 | 17 | 14 | TCCAG | 2 | 1 | ||||
TCCGG | 25 | 17 | TCTGG | 0 | 2 | 1 | TCCGG | 38 | 5 | ||||
TCTGG | 2 | 1 | TCTGG | 2 | 2 | ||||||||
P value | 0.80 | P value | 0.95 | P value | 0.24 | ||||||||
<1 | >1 | <2.6 | 2.6–5.1 | >5.1 | No | Yes | |||||||
2 to 10 years | CACGG | 12 | 14 | CACGG | 5 | 15 | 6 | CACGG | 21 | 5 | |||
CCCGA | 6 | 2 | CCCGA | 2 | 3 | 3 | CCCGA | 7 | 1 | ||||
TCCAG | 11 | 7 | CCCGG | 1 | 1 | 1 | TCCAG | 16 | 2 | ||||
TCCGG | 48 | 41 | TCCAG | 1 | 11 | 2 | TCCGG | 74 | 17 | ||||
TCTGG | 12 | 7 | TCCGG | 18 | 50 | 25 | TCTGG | 17 | 3 | ||||
TCTGG | 2 | 12 | 6 | ||||||||||
P value | 0.57 | P value | 0.81 | P value | 0.93 | ||||||||
<1 | >1 | <2.6 | 2.6–5.1 | >5.1 | No | Yes | <110 | >110 | |||||
>10 years | CACGG | 21 | 31 | CACGG | 13 | 27 | 14 | CACGG | 37 | 16 | CACGG | 3 | 4 |
CCCGA | 2 | 6 | CCCGA | 1 | 4 | 2 | CCCGA | 3 | 6 | CCCGA | 6 | 1 | |
TCCAG | 13 | 16 | TCCAG | 5 | 18 | 8 | TCCAG | 20 | 11 | TCCAG | 10 | 2 | |
TCCGG | 48 | 61 | TCCGG | 18 | 67 | 29 | TCCGG | 79 | 38 | TCCGG | 5 | 8 | |
TCTGG | 7 | 8 | TCTGG | 3 | 10 | 4 | TCTGG | 10 | 6 | TCTGG | 9 | 7 | |
P value | 0.85 | P value | 0.98 | P value | 0.30 | P value | 0.09 | ||||||
<110 | >110 | ||||||||||||
<10 years | CACGG | 3 | 9 | ||||||||||
CCCGA | 7 | 4 | |||||||||||
TCCAG | 10 | 5 | |||||||||||
TCCGG | 8 | 2 | |||||||||||
TCTGG | 1 | 6 | |||||||||||
P value | 0.01 | ||||||||||||