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Table 1 Demographic details, CV risk factors, features of RA and RA disease control in the RA study population

From: Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis

Demographics  
   Age (years) 61.8 (13.7)
   Females, n (%) 147 (63.9)
   Duration of RA (years) 15 (13)
   RF positive, n (%) 141 (62.9)
CV disease  
   History of MI, n (%) 24 (10.5)
   History of angina, n (%) 21 (9.2)
   History of stroke/TIA, n (%) 16 (7.0)
   History of PVD, n (%) 10 (4.4)
   Any vascular event, n (%) 47 (20.5)
Risk factors for CV disease  
   Smoking pack-year historya 17 (22)
   Current smoker, n (%) 52 (22.9)
   History of hypertension, n (%) 78 (33.9)
   History of hyperlipidemia, n (%) 52 (22.9)
   Use of statins in hyperlipidemia 30 (14.8)
   History of diabetes, n (%) 30 (13.3)
   Family history CV disease, n (%) 58 (26.0)
Clinical findings  
   BMI (kg/m2) 27.1 (6.4)
   Systolic BP (mmHg) 133 (19)
   Diastolic BP (mmHg) 78 (10)
Laboratory tests  
   ESR (mm/h) 25 (22)
   CRP (mg/l) 17.1 (27.4)
   Total cholesterol (mmol/l) 5.2 (1.0)
   HDL cholesterol (mmol/l) 1.5 (0.4)
   LDL cholesterol (mmol/l) 3.0 (0.9)
   LDL: HDL ratio 2.1 (0.8)
   TG (mmol/l) 1.5 (1.0)
   Homocysteine (mcmol/l) 12 (5)
   Fasting glucose (mmol/l) 5.6 (1.6)
   Serum creatinine (mmol/l) 0.08 (0.04)
   CrCl (ml/min) 82.2 (31.2)
Framingham risk score (%)b 7.0 (5.9)
ECG evidence of ischemia,c n (%) 7 (3.5)
Severity and features of RA  
   Radiographic erosion score 22 (34)
   Joint-space-narrowing score 21 (28)
   Presence of erosive disease, n (%) 160 (76.0)
   History of vasculitis, n (%) 20 (8.9)
   Shared epitope,d n (%) 144 (76.6)
   >10 mg/day of prednisone, n (%) 17 (7.4)
RAGE polymorphism,d n (%) 39 (20.4)
  1. aPackets of cigarettes per day (20 cigarettes per pack) × no. of years of smoking (includes nonsmokers).
  2. bPredicts the 5-year absolute risk of CV disease (MI, angina, coronary death, nonspecific heart disease, heart failure, PVD, stroke or TIA).
  3. c4 out of 166 (2.4%) patients without known CV disease had ECGs suggestive of prior silent ischemia.
  4. d191 patients were genotyped.
  5. Except where indicated, values are the mean (± SD). BMI, body-mass index; BP, blood pressure; CRP, C-reactive protein; CV, cardiovascular; ECG, electrocardiogram; ESR, erythrocyte sedimentation rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; MI, myocardial infarction; PVD, peripheral vascular disease; RA, rheumatoid arthritis; RF, rheumatoid factor; RAGE, receptor for advanced glycation end products; SCr, serum creatinine; SD, standard deviation; TG, triglyceride; TIA, transient ischemic attack.