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Table 1 Confirmed linkage effects in systemic lupus erythematosus

From: Current status of lupus genetics

Linkage region

LOD score

Study center

Study design

Associated gene(s)

Mouse ortholog

Cohort ethnicity

Ref(s)

1q23

4.0

OMRF

Extended pedigrees

FCGR2A, FCGR3A

sle1, nba2 [54]

EA, AA

[6,7]

1q31-32

3.8

UU

Extended pedigrees

 

sle1c [84]

EU

[6,85]

1q41-43

3.3

UCLA

USC

Extended pedigrees

PARP*

 

EA, HIS

[7,86]

2q37

4.2

UU

Extended pedigrees

PDCD-1

 

EU

[13,87]

4p16

3.8

OMRF

Extended pedigrees

 

sle6 [88]

EA

[89,90]

6p11-21

4.2

UMN

Sib-pairs

HLA-DR

sles1 [88,91]

EA, HIS, AA

[16]

10q22-23

P = 0.0002†

OMRF

UCLA

Extended pedigrees, sib-pairs

  

AA

[92-94]

12q24

3.3

OMRF

Extended pedigrees

  

HIS, EA

[95]

16q12-13

3.4

UMN

OMRF

Sib-pairs, extended pedigrees

  

EA, AA, HIS

[96,97]

  1. *Although there was initial evidence that PARP was the gene responsible for this linkage [17], subsequent studies have failed to confirm an association [18-21]. †The initial linkage at 10q22 was described using allele sharing statistics; therefore, a P value is generated instead of a log of odds (LOD) score. AA, African-Americanl EA, European-American; EU, European; HIS, Hispanic; OMRF, Oklahoma Medical Research Foundation; UCLA, University of California at Los Angeles; USC, University of Southern California; UU, Uppsala University (Sweden).