Table 1 Clinical features associated with systemic sclerosis autoantibodies
From: Clinical trials in systemic sclerosis: lessons learned and outcomes
| Â | Antibodies | |||||
|---|---|---|---|---|---|---|
| Â | ACA | Th/To | U1RNP | U3RNP | Topo | Pol III |
Patient characteristics | Female | Â | MCTD | African American | Â | Â |
Disease subtype | Limited | Limited | Limited | Diffuse | Diffuse | Diffuse |
Joint/skin involvement | ↓ Joint | ↓ Joint | ↑ Joint |  |  | ↑↑ Skin |
Muscle involvement |  |  | ↑ | ↑ |  |  |
Calcinosis | ↑ |  |  |  |  |  |
Acroosteolysis | ↑ |  |  |  | ↑ |  |
DUs | Yes | Â | Â | Â | Yes | Â |
PAH ± PF | PAH | PAH | PAH | PAH + PF | PF | ↓↓ PF |
Renal crisis |  |  |  | Yes | Yes | ↑ |