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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Falling into TRAPS – receptor misfolding in the TNF receptor 1-associated periodic fever syndrome

Figure 1

TNF receptor-associated periodic syndrome mutations in TNF receptor 1. Schematic of TNF receptor-associated periodic syndrome (TRAPS) mutations in TNF receptor 1 (TNFR1) illustrating the extreme clustering of mutations towards cysteine-rich domains CRD1 and CRD2. (a) The preligand assembly domain (PLAD), ligand binding domain, and other structural features of TNFR1 are highlighted. (b) A line model of CRD1 and CRD2 of TNFR1, with the sites of TRAPS mutations and amino acid (aa) changes indicated (red boxes).

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