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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration

Figure 3

Senescence biomarkers in human intervertebral disc (IVD) cells in vitro. (a) Cell growth kinetics: cumulative population doublings in nucleus pulposus (NP) cells extracted from non-degenerate and degenerate IVDs. (b) Percentage of life span completed over time in culture of NP cells extracted from non-degenerate and degenerate IVDs. (c) Mean telomere length in NP cells extracted from non-degenerate and degenerate IVDs with increasing population doubling. Samples used consisted of two non-degenerate discs from one post mortem (L2/3: grade 1, L4/5: grade 2; 37-year-old male) and two degenerate discs from one patient undergoing surgery (L4/5: grade 4, L5/S1: grade 8; 49-year-old male).

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