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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration

Figure 4

Correlation of senescent phenotype with expression of matrix-degrading enzymes. (a) Correlation of MMP-13 and p16INK4a gene expression in human intervertebral disc (IVD) cells. Spearman rank correlation P < 0.05. (b) Correlation of ADAMTS 5 and p16INK4a gene expression in human IVD cells. Spearman rank correlation P < 0.05. ADAMTS 5, a disintegrin and metalloprotease with thrombospondin motifs 5; MMP-13, matrix metalloproteinase-13.

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