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Table 1 Features of major human dendritic cell subsets

From: Cells of the synovium in rheumatoid arthritis. Dendritic cells

  Dendritic cell subset
  Myeloid (also known as conventional)  
Feature Epithelial Langerhans cells Interstitial tissue dendritic cells Plasmacytoid
Progenitors CD34+, giving rise to common myeloid progenitors, common lymphoid progenitors, monocytes CD34+, common myeloid progenitors, common lymphoid progenitors
Progenitor homeostatic and expansion factors FLT3-L, granulocyte/macrophage colony-stimulating factor, stem cell factor, IL-4 FLT3-L, IL-3
  Transforming growth factor beta, TNF   
Specific markers Langerin, E-cadherin, CD1a DC-SIGN, CD1c, BDCA3, S100 CD123, BDCA-2, BDCA-4
Toll-like receptors All except TLR7, TLR8 TLR1, TLR2, TLR4, TLR5, TLR8 TLR7, TLR9
Major cytokines produced   IL-12 IFN-α
  Produce proinflammatory and anti-inflammatory cytokines and chemokines in response to a variety of signals
Tissue location Epithelium and epithelial draining lymph nodes Nonepithelial tissues, lymph node, spleen, thymus Lymph node, spleen, inflamed tissues
Found in rheumatoid arthritis synovium Yes (CD1a+ dendritic cells) Yes Yes