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Table 2 Arthritic Bid-/- mice have elevated levels of serum KC and IL-1β

From: Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis

  Day 0 Day 3 Day 5
  Wt Bid-/- Wt Bid-/- Wt Bid-/-
G-CSF 56.0 ± 42.0 45.6 ± 9.3 454.1 ± 92.5 488.1 ± 84.3 869.9 ± 366.0 496.7 ± 91.2
GM-CSF UD UD 9.6 ± 9.6 115.7 ± 54.3 58.8 ± 58.8 20.7 ± 20.7
IL-10 UD UD UD 61.6 ± 45.3 111.7 ± 60.3 16.7 ± 16.7
IL-12 (p70) UD 9.2 ± 9.2 UD 22.1 ± 10.4 29.4 ± 20.8 UD
IL-1β 3.7 ± 1.3 3.5 ± 1.5 24.3 ± 2.6 43.6 ± 8.8 (p < 0.09) 44.72 ± 4.2 34.1 ± 3.0
IL-6 2.4 ± 1.6 0.6 ± 0.6 165.3 ± 31.5 240.6 ± 38.2 207.2 ± 53.2 166.9 ± 19.9
KC 7.2 ± 3.5 3.9 ± 2.5 53.8 ± 7.9 108.2 ± 13.2 (p < 0.01) 113.5 ± 25.6 75.2 ± 8.1
MCP-1 1.2 ± 1.2 4.8 ± 4.8 1.0 ± 0.2 3.2 ± 1.9 2.8 ± 0.8 2.2 ± 0.1
MIP1α 7.5 ± 3.0 60.5 ± 40.5 100.9 ± 28.2 161.5 ± 27.3 186.9 ± 17.3 191.0 ± 32.1
RANTES 1.2 ± 0.8 24.6 ± 24.6 5.8 ± 0.6 6.9 ± 0.9 9.7 ± 2.0 6.6 ± 0.7
TNFα 3.0± 0.4 3.1 ± 0.4 7.7 ± 2.6 13.0 ± 6.4 15.6 ± 2.3 15.2 ± 0.9
  1. Wild-type (Wt) (n = 5/tp) and Bid-/- (n = 5/tp) mice were euthanized at three or five days post-serum transfer. Peripheral blood was isolated by cardiac stick, and serum was separated by centrifugation and examined for production of the indicated cytokine or chemokine (pg/ml) using a Luminex based assay. Values represent the mean ± standard error, which were compared by Student's t-test. G-CSF, granulocyte colony stimulating factor; GM-CSF, granulocyte-macrophage colony stimulating factor; KC, CXC chemokine; MCP, monocyte chemoattractant protein; MIP1α, Macrophage inflammatory protein 1α; RANTES, regulated upon activation, normal T-cell expressed, and secreted; TNF, tumor necrosis factor; UD, undetectable.