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Table 2 Arthritic Bid-/- mice have elevated levels of serum KC and IL-1β

From: Pro-apoptotic Bid is required for the resolution of the effector phase of inflammatory arthritis

 

Day 0

Day 3

Day 5

 

Wt

Bid-/-

Wt

Bid-/-

Wt

Bid-/-

G-CSF

56.0 ± 42.0

45.6 ± 9.3

454.1 ± 92.5

488.1 ± 84.3

869.9 ± 366.0

496.7 ± 91.2

GM-CSF

UD

UD

9.6 ± 9.6

115.7 ± 54.3

58.8 ± 58.8

20.7 ± 20.7

IL-10

UD

UD

UD

61.6 ± 45.3

111.7 ± 60.3

16.7 ± 16.7

IL-12 (p70)

UD

9.2 ± 9.2

UD

22.1 ± 10.4

29.4 ± 20.8

UD

IL-1β

3.7 ± 1.3

3.5 ± 1.5

24.3 ± 2.6

43.6 ± 8.8 (p < 0.09)

44.72 ± 4.2

34.1 ± 3.0

IL-6

2.4 ± 1.6

0.6 ± 0.6

165.3 ± 31.5

240.6 ± 38.2

207.2 ± 53.2

166.9 ± 19.9

KC

7.2 ± 3.5

3.9 ± 2.5

53.8 ± 7.9

108.2 ± 13.2 (p < 0.01)

113.5 ± 25.6

75.2 ± 8.1

MCP-1

1.2 ± 1.2

4.8 ± 4.8

1.0 ± 0.2

3.2 ± 1.9

2.8 ± 0.8

2.2 ± 0.1

MIP1α

7.5 ± 3.0

60.5 ± 40.5

100.9 ± 28.2

161.5 ± 27.3

186.9 ± 17.3

191.0 ± 32.1

RANTES

1.2 ± 0.8

24.6 ± 24.6

5.8 ± 0.6

6.9 ± 0.9

9.7 ± 2.0

6.6 ± 0.7

TNFα

3.0± 0.4

3.1 ± 0.4

7.7 ± 2.6

13.0 ± 6.4

15.6 ± 2.3

15.2 ± 0.9

  1. Wild-type (Wt) (n = 5/tp) and Bid-/- (n = 5/tp) mice were euthanized at three or five days post-serum transfer. Peripheral blood was isolated by cardiac stick, and serum was separated by centrifugation and examined for production of the indicated cytokine or chemokine (pg/ml) using a Luminex based assay. Values represent the mean ± standard error, which were compared by Student's t-test. G-CSF, granulocyte colony stimulating factor; GM-CSF, granulocyte-macrophage colony stimulating factor; KC, CXC chemokine; MCP, monocyte chemoattractant protein; MIP1α, Macrophage inflammatory protein 1α; RANTES, regulated upon activation, normal T-cell expressed, and secreted; TNF, tumor necrosis factor; UD, undetectable.
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Arthritis Research & Therapy

ISSN: 1478-6362

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