Figure 2From: Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in miceHind paw images of DBA mice. (a) Hind paws of healthy non-immunized DBA mice. (b) Type II collagen-immunized (arthritic) DBA mice treated with 1-methyl-tryptophan 6 to 7 days after the onset of collagen-induced arthritis. (c) Type II collagen-immunized (arthritic) DBA mice treated with vehicle 6 to 7 days after the onset of collagen-induced arthritis. According to our scoring system (see Materials and methods), the three stages have been assigned scores of 0 (a), 4 (b), and 3 (c).Back to article page