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Figure 2 | Arthritis Research & Therapy

Figure 2

From: High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis

Figure 2

Expression of Fc gamma receptor (FcγR)IIb in healthy and rheumatoid arthritis (RA) synovia. (a) FcγRIIb was sparsely expressed in the few healthy synovial biopsies that were positively stained by GB3. The arrows indicate FcγRIIb positive cells in the sub-lining synovial layer and tissue. (b) The IgG1 isotype control antibody did not stain the healthy synovium. (c,e) Positive FcγRIIb expression was found in all the stained RA synovial biopsies. FcγRIIb staining was observed in the synovial lining and sub-lining layers, perivasculary and inside lymphocyte infiltrates (e). (d) No staining of the RA synovium was observed when the anti-FcγRIIb monoclonal antibody was bound by recombinant human soluble FcγRIIb prior to staining. (f) Synovial FcγRIIb expression was significantly up-regulated in RA patients (n = 10) compared to healthy individuals (n = 5) (mean values of two independent observers, SEM and SK with standard error of the mean, *p = 0.0104). DAB, diaminobenzidine. (Original magnification ×125.)

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