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Table 4 Multivariate analysis of significant variables and other likely causational variables for serious NSAID ulcer complications

From: Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study

Predictor

Adjusted OR

95% CI

p

Proton-pump inhibitors

0.33

0.17–0.67

0.002

Coumarin

2.09

0.93–4.70

0.075

Heart failure

2.44

1.28–4.66

0.007

Acetaminophen

2.80

1.64–4.79

<0.001

Low-molecular-mass heparin

17.33

3.71–80.95

<0.001

  1. Serious non-steroidal anti-inflammatory drug (NSAID) ulcer complication was the dependent variable. Only variables from the final parsimonious model are shown. OR, odds ratio; CI, confidence interval.