Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study

Table 5 Multivariate analysis after exclusion of patients with in-hospital NSAID ulcer complications

Predictor	Adjusted OR	95% CI	p
Proton-pump inhibitors	0.31	0.15–0.66	0.002
Coumarin	2.38	1.03–5.48	0.04
Heart failure	2.10	1.04–4.21	0.04
Acetaminophen	2.47	1.39–4.39	0.002
Low-molecular-mass heparin	6.06	0.91–40.60	0.06

Serious non-steroidal anti-inflammatory drug (NSAID) ulcer complication was the dependent variable. Only variables from the final parsimonious model are shown. OR, odds ratio; CI, confidence interval.

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