Figure 4
Expression of iNOS in the right and left dorsal horns of monoarthritic rats. Inducible nitric oxide synthase (iNOS) expression was measured 6 and 24 hours after intrathecal administration of (±)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) (a) and ketamine (b). Bar graphs show iNOS expression in standardized units (means ± SEM); below each bar graph a representative example of immunodot blotting is shown. Both CPP and ketamine increased iNOS expression compared with saline-injected monoarthritic controls (*P < 0.05 compared with control; Kruskal–Wallis test).