|
Time course
|
Cytokines
|
Accession number
|
4 hours pi
|
1 day pi
|
7 days pi
|
|---|
|
3 time points
|
IFN-γ
|
X01992
|
+++
|
++
|
+
|
|
2 time points
|
IL-5
|
X04688
|
+++
|
+
|
-
|
| |
IL-1-β
|
K02770
|
-
|
+
|
+
|
| |
IL-10
|
M57627
|
-
|
+
|
+
|
| |
TGF-β-2
|
M19154
|
-
|
+
|
+
|
|
1 time point
|
TNF-α
|
X01394
|
+++
|
-
|
-
|
| |
LIF
|
X13967
|
+++
|
-
|
-
|
| |
IL-4
|
M13982
|
+++
|
-
|
-
|
| |
IL-6
|
X04602
|
+++
|
-
|
-
|
| |
IL-15
|
U14407
|
+
|
-
|
-
|
| |
IL-16
|
M90391
|
+
|
-
|
-
|
| |
IL-17 (CTLA8)
|
U32659
|
+++
|
-
|
-
|
| |
IL-18
|
D49950
|
+++
|
-
|
-
|
| |
IL-1-α
|
X02851
|
-
|
+
|
-
|
| |
IL-3
|
M14743
|
-
|
+
|
-
|
| |
IL-9
|
X17543
|
-
|
+
|
-
|
| |
IL-11
|
M57765
|
-
|
+
|
-
|
| |
TGF-β-1
|
X02812
|
-
|
-
|
+
|
- The table shows mRNA transcripts encoding for cytokines as found to be expressed by microarray in Chlamydia trachomatis-infected human monocytes over a time course of up to 7 days. Signal intensity is given as fold of expression as compared with the mock-infected probe. Fold of expression for microarray as well as for reverse transcription-polymerase chain reaction data is indicated by '-' (less than 2), '+' (more than or equal to 2 and less than 10), '++' (more than or equal to 10 and less than 100), and '+++' (more than or equal to 100). Gene expression was studied at three different time points: 4 hours pi indicates the very early phase of active infection, whereas day 1 corresponds to a transition (that is, the beginning of growth arrest) and day 7 represents persistent infection. IFN, interferon; IL, interleukin; LIF, leukemia inhibitory factor; pi, post-infection; TGF, transforming growth factor; TNF, tumor necrosis factor.
