Time course | Cytokines | Accession number | 4 hours pi | 1 day pi | 7 days pi |
---|
3 time points | IFN-γ | X01992 | +++ | ++ | + |
2 time points | IL-5 | X04688 | +++ | + | - |
 | IL-1-β | K02770 | - | + | + |
 | IL-10 | M57627 | - | + | + |
 | TGF-β-2 | M19154 | - | + | + |
1 time point | TNF-α | X01394 | +++ | - | - |
 | LIF | X13967 | +++ | - | - |
 | IL-4 | M13982 | +++ | - | - |
 | IL-6 | X04602 | +++ | - | - |
 | IL-15 | U14407 | + | - | - |
 | IL-16 | M90391 | + | - | - |
 | IL-17 (CTLA8) | U32659 | +++ | - | - |
 | IL-18 | D49950 | +++ | - | - |
 | IL-1-α | X02851 | - | + | - |
 | IL-3 | M14743 | - | + | - |
 | IL-9 | X17543 | - | + | - |
 | IL-11 | M57765 | - | + | - |
 | TGF-β-1 | X02812 | - | - | + |
- The table shows mRNA transcripts encoding for cytokines as found to be expressed by microarray in Chlamydia trachomatis-infected human monocytes over a time course of up to 7 days. Signal intensity is given as fold of expression as compared with the mock-infected probe. Fold of expression for microarray as well as for reverse transcription-polymerase chain reaction data is indicated by '-' (less than 2), '+' (more than or equal to 2 and less than 10), '++' (more than or equal to 10 and less than 100), and '+++' (more than or equal to 100). Gene expression was studied at three different time points: 4 hours pi indicates the very early phase of active infection, whereas day 1 corresponds to a transition (that is, the beginning of growth arrest) and day 7 represents persistent infection. IFN, interferon; IL, interleukin; LIF, leukemia inhibitory factor; pi, post-infection; TGF, transforming growth factor; TNF, tumor necrosis factor.