|
Time course
|
Receptors
|
Accession number
|
4 hours pi
|
1 day pi
|
7 days pi
|
|---|
|
3 time points
|
IL-2R-γ
|
D11086
|
+ (+)
|
+ (-)
|
+ (+)
|
|
1 time point
|
IL-2R-β (CD122)
|
M26062
|
+
|
-
|
-
|
| |
IL-5R-α (CD125)
|
M75914
|
-
|
+
|
-
|
| |
TNFR
|
M32315
|
-
|
-
|
+
|
- The table shows mRNA transcripts encoding for cytokine and chemokine receptors as found to be expressed by microarray in Chlamydia trachomatis-infected human monocytes over a time course of up to 7 days. Microarray ratios of interleukin-2 receptor-gamma (IL-2R-γ) were confirmed by quantitative real-time reverse transcription-polymerase chain reaction (noted in parentheses) (see Figures 1–3). Fold of expression for microarray as well as for reverse transcription-polymerase chain reaction data is indicated by '-' (less than 2), '+' (more than or equal to 2 and less than 10), '++' (more than or equal to 10 and less than 100), and '+++' (more than or equal to 100). Gene expression was studied at three different time points: 4 hours pi indicates the very early phase of active infection, whereas day 1 corresponds to a transition (that is, the beginning of growth arrest) and day 7 represents persistent infection. IL-5R-α, interleukin-5 receptor-alpha; TNFR, tumor necrosis factor receptor.
