Time course | Receptors | Accession number | 4 hours pi | 1 day pi | 7 days pi |
|---|
3 time points | IL-2R-γ | D11086 | + (+) | + (-) | + (+) |
1 time point | IL-2R-β (CD122) | M26062 | + | - | - |
|  | IL-5R-α (CD125) | M75914 | - | + | - |
| Â | TNFR | M32315 | - | - | + |
- The table shows mRNA transcripts encoding for cytokine and chemokine receptors as found to be expressed by microarray in Chlamydia trachomatis-infected human monocytes over a time course of up to 7 days. Microarray ratios of interleukin-2 receptor-gamma (IL-2R-γ) were confirmed by quantitative real-time reverse transcription-polymerase chain reaction (noted in parentheses) (see Figures 1–3). Fold of expression for microarray as well as for reverse transcription-polymerase chain reaction data is indicated by '-' (less than 2), '+' (more than or equal to 2 and less than 10), '++' (more than or equal to 10 and less than 100), and '+++' (more than or equal to 100). Gene expression was studied at three different time points: 4 hours pi indicates the very early phase of active infection, whereas day 1 corresponds to a transition (that is, the beginning of growth arrest) and day 7 represents persistent infection. IL-5R-α, interleukin-5 receptor-alpha; TNFR, tumor necrosis factor receptor.
