Table 2 Frequency distribution of the 1858 C/T polymorphism of PTPN22 in patients with early rheumatoid arthritis and matched controls
Genotype | Patients (n = 504) | Controls (n = 970) | χ2 | P value | Pc value | Odds ratio | 95% confidence interval | ||
|---|---|---|---|---|---|---|---|---|---|
n | % | n | % | ||||||
CC | 338 | 67.1 | 761 | 78.5 | 22.68 | 0.000002 | 0.00001 | 0.56 | 0.44–0.72 |
CT | 151 | 30.0 | 196 | 20.2 | 17.53 | 0.000028 | 0.00014 | 1.69 | 1.31–2.18 |
TT | 15 | 3.0 | 13 | 1.3 | 4.76 | 0.02907 | 0.14535 | 2.26 | 1.01–5.08 |
CT + TT | 166 | 33.0 | 209 | 21.5 | 22.68 | 0.000002 | 0.00001 | 1.79 | 1.40–2.29 |
T allele | 181 | 18.0 | 222 | 11.4 | 23.84 | 0.000001 | 0.000005 | 1.69 | 1.36–2.11 |