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Table 5 Relative risk for developing rheumatoid arthritis in patients, stratified for anti-cyclic citrullinated peptide (anti-CCP) antibodies

From: The PTPN221858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden

  Non-T carrier (CC) T carrier (CT, TT)
  Cases/controls Relative risk (95% confidence interval) Cases/controls Relative risk (95% confidence interval)
Anti-CCP antibody-positive
   Smoking-negative 59/511 1.00 37/146 2.17 (1.41–3.35)
   Smoking-positive 142/192 6.29 (4.51–8.77) 73/50 12.54 (8.11–19.40)
Anti-CCP antibody-negative
   Smoking-negative 47/511 1.00 17/146 1.36 (0.80–2.33)
   Smoking-positive 60/192 3.71 (2.51–5.46) 23/50 5.87 (3.46–9.95)
  1. The combination of carriage or not of the 1858T variant of the PTPN22 gene and ever or never smoking were compared for groups stratified for anti-CCP antibodies.