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Table 6 Relative risk for developing rheumatoid arthritis in patients, stratified for anti-cyclic citrullinated peptide (anti-CCP) antibodies

From: The PTPN221858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden

  Nonsmoking Smoking
  Cases/controls Relative risk (95% confidence interval) Cases/controls Relative risk (95% confidence interval)
Anti-CCP antibody-positive
   HLA-shared epitope-positive 33/41 1.00 71/49 1.67 (0.95–2.94)
   HLA-shared epitope-negative 62/33 2.05 (1.12–3.75) 143/21 7.61 (4.05–14.30)
Anti-CCP antibody-negative
   HLA-shared epitope-positive 40/41 1.00 52/49 1.11 (0.63–1.95)
   HLA-shared epitope-negative 23/33 0.71 (0.37–1.38) 31/21 1.92 (0.98–3.77)
  1. The combination of carriage of HLA-shared epitope alleles or not, and ever or never smoking were compared for groups stratified for anti-CCP antibodies.