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Table 4 DRB1/DQA1 genotype distribution in rheumatic fever and rheumatic heart disease patients compared with control subjects

From: HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children

 

Genotype

Group

*07/*0201

*01/*0501

*04/*0401

All RF (n = 70)

0.09/2.01 (0.06)

0.08/3.18 (0.005)

0.01/0.23

MVR (n = 24)

0.06

0.06

ND

MVL (n = 20)

0.1

0.01/5.69 (0.001)

ND

Sydenham's chorea (n = 8)

0.18/3.72 (0.04)

0.05

ND

Without RHD (n = 23)

0.13/2.79 (0.02)

0.06

0.001/11.10 (0.004)

Control subjects (n = 100)

0.05

1.44/0.23

0.19/0.65

  1. Values are allele frequency/odds ratio (p value) and are reported only for significant associations (p < 0.05); n = number of haplotypes (for example, 140 alleles from 70 individuals and 200 alleles from 100 individuals). MVL, multivalvular lesion (mitral regurgitation + aortic valve regurgitation; MVR, mitral valve regurgitation; ND, not determined; RF, rheumatic fever; RHD, rheumatic heart disease.