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Table 5 DQA1/DQB1 genotype distribution in rheumatic fever and rheumatic heart disease patients compared with control subjects

From: HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children

 

Genotype

Group

*0102/*0602-8

*0501/*0301

*0501/*0201-2

*0301/*0402

All RF (n = 70)

0.09

0.19/2.10 (0.01)

0.01/0.26 (0.05)

0.03/7.06 (0.03)

MVR (n = 24)

0.06

0.15

0.02

ND

MVL (n = 20)

0.12

0.25/3.35 (0.01)

ND

0.02

Sydenham's chorea (n = 8)

0.12

0.12

ND

0.12/38.83 (0.005)

Without RHD (n = 23)

0.12

0.22/2.58 (0.03)

0.02

0.07/17.48 (0.0005)

Control subjects (n = 100)

0.12/198.63 (0.00)

0.11

0.05

0.004

  1. Values are allele frequency/odds ratio (p value) and are reported only for significant associations (p < 0.05); n = number of haplotypes (for example, 140 alleles from 70 individuals and 200 alleles from 100 individuals). MVL, multivavular lesion (mitral regurgitation + aortic valve regurgitation); MVR, mitral valve regurgitation; ND, not determined; RF, rheumatic fever; RHD, rheumatic heart disease.