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Table 5 DQA1/DQB1 genotype distribution in rheumatic fever and rheumatic heart disease patients compared with control subjects

From: HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children

  Genotype
Group *0102/*0602-8 *0501/*0301 *0501/*0201-2 *0301/*0402
All RF (n = 70) 0.09 0.19/2.10 (0.01) 0.01/0.26 (0.05) 0.03/7.06 (0.03)
MVR (n = 24) 0.06 0.15 0.02 ND
MVL (n = 20) 0.12 0.25/3.35 (0.01) ND 0.02
Sydenham's chorea (n = 8) 0.12 0.12 ND 0.12/38.83 (0.005)
Without RHD (n = 23) 0.12 0.22/2.58 (0.03) 0.02 0.07/17.48 (0.0005)
Control subjects (n = 100) 0.12/198.63 (0.00) 0.11 0.05 0.004
  1. Values are allele frequency/odds ratio (p value) and are reported only for significant associations (p < 0.05); n = number of haplotypes (for example, 140 alleles from 70 individuals and 200 alleles from 100 individuals). MVL, multivavular lesion (mitral regurgitation + aortic valve regurgitation); MVR, mitral valve regurgitation; ND, not determined; RF, rheumatic fever; RHD, rheumatic heart disease.