Figure 1

Central components of the transforming growth factor (TGF)-β pathway are shown with their scores, as determined by Gene Set Enrichment Analysis of the oligonucleotide microarray data. Molecules upregulated in synovial fibroblast (SFBs) from rheumatoid arthritis patients are shown in red (negative values), and those upregulated in osteoarthritis SFBs are shown in green (positive values). Red arrow indicates the cleavage site. CBP, CREB binding protein; LAP, latency-associated protein; LTBP, latent TGF-β binding protein; P, phosphate; TGFBR, TGF-β receptor; TGIF, TGFB-induced factor; THBS, thrombospondin.