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Table 3 Analysis of the effect of infliximab on BMD using different linear regression models

From: A 1-year case-control study in patients with rheumatoid arthritis indicates prevention of loss of bone mineral density in both responders and nonresponders to infliximab

Models

Cofactors

Femoral neck BMD

Lumbar BMD

  

BMD variation

P

BMD variation

P

1

Infliximab

0.027

0.001

0.030

0.001

2

Infliximab

0.027

0.001

0.031

0.001

 

Male sex

-0.009

0.40

0.008

0.47

 

Age

0.002

0.56

0.005

0.09

3

Infliximab

0.020

0.03

0.033

0.001

 

Male sex

-0.014

0.22

0.006

0.64

 

Age

0.001

0.86

0.005

0.15

 

Patients on steroids

-0.012

0.20

-0.001

0.92

4

Infliximab

0.023

0.01

0.034

0.001

 

Male

-0.014

0.22

0.006

0.61

 

Age

-0.001

0.90

-0.001

0.88

 

Menopause

0.005

0.75

0.022

0.20

 

Patients on steroids

-0.010

0.29

-0.002

0.87

 

DAS28

-0.008

0.04

-0.006

0.17

5

Infliximab

0.023

0.02

0.035

0.001

 

Male

-0.015

0.20

0.007

0.58

 

Age

-0.001

0.85

0.000

0.95

 

Menopause

0.006

0.70

0.020

0.25

 

Patients on steroids

-0.009

0.37

-0.004

0.65

 

DAS28

-0.008

0.05

-0.006

0.15

 

Patients on biphosphonates

-0.012

0.29

0.022

0.07

6

Infliximab

0.028

0.002

0.041

0.001

 

Male

-0.007

0.53

0.010

0.39

 

Age

-0.002

0.61

0.002

0.63

 

Patients on steroids

-0.008

0.35

-0.001

0.91

 

DAS28

-0.007

0.06

-0.007

0.10

 

Baseline BMD values

-0.042

0.16

-0.080

0.01

  1. All 189 patients were included in several analysis of covariance models for bone mineral density (BMD) variations (final values minus initial values) to analyze the effect of cofactors (continuous variables and discrete variables) on that of infliximab. DAS, Disease Activity Score.