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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Celastrus aculeatusMerr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65

Figure 1

Feeding of Celastrus suppresses the induction of adjuvant arthritis (AA) in the Lewis (LEW) rat. (a) LEW rats (n = 7 per group) were fed by gavage daily either Celastrus (triangles; 3 g/kg body weight, experimental group) or water (circles; control group) starting on day 4 prior to M. tuberculosis H37Ra (Mtb) immunization (1 mg/rat) and then continuing throughout the observation period. Following Mtb injection, these rats were scored regularly for signs of arthritis. The difference in the mean arthritic scores of the Celastrus-fed and Water-fed rats during the course of AA was significant (*p < 0.05 by Wilcoxon rank sum test). (b) The results of an independent repeat experiment including two groups of Celastrus-treated rats are shown in this section. The difference in arthritic scores of Celastrus-fed versus Water-fed rats was significant (*p < 0.05) for each of the groups tested (triangles; 1.5 g/kg, n = 4; squares, 3 g/kg, n = 4). (c) The photograph shows the hind paw of a representative LEW rat from the water-fed (left) and Celastrus-fed (middle) groups on day 16 after Mtb immunization. The hind paw of a naive LEW rat (right) is also shown for comparison; each unit on the scale equals 1 mm, with 10 units between numbered marks.

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