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Table 2 GH secretory parameters and morning serum concentrations of IGF-I and IGFBPs in rheumatoid arthritis patients and control subjects

From: Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study

Variables Rheumatoid arthritis (n = 7) Controls (n = 10) P value
GH basal secretion (μg/liter per minute) 0.02 ± 0.00 0.01 ± 0.00 NS
GH mass/burst (μg/liter) 6.12 ± 1.03 6.71 ± 1.20 NS
GH burst frequency (number/24 hours) 13.7 ± 1.9 9.8 ± 1.2 NS
GH amplitude (μg/liter per minute) 0.430 ± 0.10 0.29 ± 0.06 NS
GH total production rate (μg/liter per 24 hours) 114 ± 26 73 ± 74 0.28
Mean GH (μg/liter) 0.91 ± 0.14 1.20 ± 0.17 NS
Integrated GH (μg/liter per minute) 1,316 ± 201 1,717 ± 245 NS
GH half-life (minutes) 9.2 ± 1.2 14.6 ± 0.9 0.0037
GH approximate entropy 0.75 ± 0.07 0.70 ± 0.09 NS
IGF-I (ng/ml) 129 ± 27 205 ± 25 0.05
IGFBP-1 (ng/ml) 42.1 ± 16 8.3 ± 2 0.066
IGFBP-3 (ng/ml) 2.2 ± 0.2 2.6 ± 0.1 0.058
  1. Values are presented as mean ± standard error. P value indicates the significance of the difference in each parameter value between patients and control subjects. See 'Statistical analysis' section for details. GH, growth hormone; IGF-I, insulin-like growth factor-1; IGFBP, insulin-like growth factor-binding protein; NS, not significant (p > 0.10 when not explicitly reported).