Baseline characteristics | Medial central femoral condyle | Medial central tibial plateau | Both areas (medial compartment) | Joint space width (mm) | ||||
---|---|---|---|---|---|---|---|---|
P value | P value | P value | P value | |||||
Age | -0.13 | 0.18 | -0.07 | 0.49 | -0.11 | 0.26 | -0.05 | 0.58 |
Gender | 0.12 | 0.24 | 0.08 | 0.41 | 0.11 | 0.26 | 0.04 | 0.66 |
Body mass index | -0.21 | 0.03 | -0.21 | 0.03 | -0.23 | 0.02 | -0.07 | 0.48 |
Alcohol | 0.02 | 0.86 | 0.02 | 0.82 | 0.02 | 0.82 | 0.18 | 0.06 |
Smoking | 0.74 | 0.45 | 0.09 | 0.36 | 0.09 | 0.35 | 0.06 | 0.55 |
SF-36 | -0.14 | 0.14 | -0.03 | 0.79 | -0.09 | 0.34 | -0.05 | 0.61 |
WOMAC total | -0.05 | 0.61 | -0.02 | 0.82 | 0.02 | 0.88 | 0.08 | 0.41 |
WOMAC subscale | ||||||||
Pain | 0.10 | 0.30 | 0.05 | 0.58 | 0.09 | 0.38 | 0.14 | 0.14 |
Stiffness | 0.04 | 0.68 | -0.07 | 0.46 | -0.06 | 0.52 | -0.0005 | 0.99 |
Function | -0.05 | 0.62 | -0.03 | 0.76 | 0.01 | 0.92 | 0.08 | 0.42 |
Patient global | 0.04 | 0.65 | 0.12 | 0.90 | 0.03 | 0.75 | -0.0004 | 0.99 |
Joint space width (mm) | 0.29 | 0.003 | -0.28 | 0.03 | 0.32 | 0.001 | -- | -- |
Meniscal extrusion | -0.31 | 0.001 | -0.26 | 0.007 | -0.32 | 0.001 | -0.16 | 0.11 |
Severe meniscal extrusion | -0.33 | 0.001 | -0.40 | 0.0001 | -0.41 | 0.0001 | -0.16 | 0.10 |
Medial meniscal tear | -0.26 | 0.006 | -0.11 | 0.25 | -0.21 | 0.03 | -0.32 | 0.001 |
Severe medial meniscal tear | -0.36 | 0.0001 | -0.29 | 0.003 | -0.36 | 0.0001 | -0.32 | 0.001 |
Lateral meniscal tear | 0.21 | 0.03 | 0.05 | 0.60 | 0.15 | 0.13 | -0.09 | 0.33 |
Severe lateral meniscal tear | 0.07 | 0.49 | 0.04 | 0.65 | 0.06 | 0.52 | 0.16 | 0.11 |
Bone hypersignal | -0.26 | 0.008 | -0.23 | 0.02 | -0.27 | 0.005 | -0.11 | 0.25 |
Bone hypersignal in the medial compartment | -0.11 | 0.23 | -0.10 | 0.30 | -0.12 | 0.21 | -0.03 | 0.76 |
Bone hypersignal in the lateral compartment | -0.32 | 0.001 | -0.31 | 0.001 | -0.35 | 0.0001 | -0.13 | 0.17 |
Changes in selected clinical variables at 24 months | Medial central femoral condyle | Medial central tibial plateau | Both areas (medial compartment) | Joint space narrowing | ||||
P value | P value | P value | P value | |||||
SF-36 | 0.07 | 0.44 | 0.12 | 0.23 | 0.11 | 0.27 | 0.10 | 0.31 |
WOMAC total | -0.05 | 0.58 | -0.10 | 0.31 | -0.09 | 0.38 | -0.23 | 0.02 |
WOMAC subscale | ||||||||
Pain | -0.15 | 0.12 | -0.21 | 0.03 | -0.21 | 0.03 | -0.29 | 0.002 |
Stiffness | 0.02 | 0.85 | -0.03 | 0.74 | 0.009 | 0.93 | -0.18 | 0.07 |
Function | -0.04 | 0.68 | -0.07 | 0.45 | -0.06 | 0.51 | -0.23 | 0.02 |
Patient global | -0.17 | 0.08 | -0.17 | 0.08 | -0.19 | 0.05 | -0.02 | 0.83 |
Joint space narrowing | 0.40 | 0.003 | 0.21 | 0.003 | 0.34 | <0.0001 | -- | -- |