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Table 3 Summary of gene and protein expression differences seen compared to non-degenerate discs

From: Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile

Target Gene expression Protein expression
IL-1β   
   Degenerate discs Proportion of samples ↑ and level ↑ (P < 0.05) ↑ in NP and IAF (P < 0.05)
   Herniated discs Proportion of samples ↑ (P < 0.05) ↑ in NP and IAF (P < 0.05)
IL-1 receptor   
   Degenerate discs Proportion of samples ↑ and level ↑ (P < 0.05) ↑ in NP (P < 0.05)
   Herniated discs Proportion of samples NC, level ↑ (P > 0.05) ↑ in NP (P < 0.05)
TNFα   
   Degenerate discs Proportion of samples ↑ (P < 0.05), level NC ↑ in NP and IAF (P < 0.05)
   Herniated discs Proportion of samples ↑ (P < 0.05), level NC ↑ in NP (P < 0.05)
TNF receptor   
   Degenerate discs Proportion of samples NC, level ↓ (P < 0.05) ↓ in NP and IAF (P > 0.05)
   Herniated discs Proportion of samples ↓ (P < 0.05), level NC ↓ in NP (P > 0.05)
  1. Up and down arrows indicate increase and decrease, respectively. IAF, inner annulus fibrosus; NC, no change; NP, nucleus pulposus.