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Table 3 Summary of gene and protein expression differences seen compared to non-degenerate discs

From: Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile

Target

Gene expression

Protein expression

IL-1β

  

   Degenerate discs

Proportion of samples ↑ and level ↑ (P < 0.05)

↑ in NP and IAF (P < 0.05)

   Herniated discs

Proportion of samples ↑ (P < 0.05)

↑ in NP and IAF (P < 0.05)

IL-1 receptor

  

   Degenerate discs

Proportion of samples ↑ and level ↑ (P < 0.05)

↑ in NP (P < 0.05)

   Herniated discs

Proportion of samples NC, level ↑ (P > 0.05)

↑ in NP (P < 0.05)

TNFα

  

   Degenerate discs

Proportion of samples ↑ (P < 0.05), level NC

↑ in NP and IAF (P < 0.05)

   Herniated discs

Proportion of samples ↑ (P < 0.05), level NC

↑ in NP (P < 0.05)

TNF receptor

  

   Degenerate discs

Proportion of samples NC, level ↓ (P < 0.05)

↓ in NP and IAF (P > 0.05)

   Herniated discs

Proportion of samples ↓ (P < 0.05), level NC

↓ in NP (P > 0.05)

  1. Up and down arrows indicate increase and decrease, respectively. IAF, inner annulus fibrosus; NC, no change; NP, nucleus pulposus.