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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes

Figure 1

Frequency of serum autoantibodies to 21 autoantigens in 100 French Canadian patients with autoimmune myositis. Autoantibodies were observed to 19 (90%) of the specificities tested. Anti-OJ and anti-EJ (both anti-synthetases) were not detected. One or more autoantibodies were present in 80% of patients. Autoantibodies to synthetases (Jo-1, PL-7, PL-12, and KS) and systemic sclerosis autoantibodies were present overall in 22% and 9% of patients, respectively. The overall frequency is over 100% because 44% of patients had more than one autoantibody. Anti-Ro were determined by ALBIA whereas anti-Ro52 and anti-Ro60 fine specificities were identified by ELISA. See Materials and methods (in the text) for a description of immunoasssays. ALBIA, addressable laser bead immunoassay; CENP, centromere protein; ELISA, enzyme-linked immunosorbent assay; RNAPOLIII, RNA polymerase III; SRP, signal recognition particle; TOPO, topoisomerase I.

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Arthritis Research & Therapy

ISSN: 1478-6362

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