Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes

Table 3 Patterns of associations between single autoantibodies in 100 patients with autoimmune myositis

	Ro	Ku	Jo-1	PL-7	PL-12	KS	U1RNP	Fibrillarin	La	PM-Scl	Topo	RNAPOLIII	CENP-B	Th	Mi-2	NUP	SRP	U5RNP	U2RNP
n	31	23	15	5	1	1	15	14	14	9	3	2	2	2	6	3	2	1	1
Methods of detection	ALBIA	LIA, IPP	LIA, IPP, ALBIA	LIA, IPP	LIA, IPP	IPP	IPP, ALBIA	TNT, ALBIA	ALBIA, ELISA	LIA, IPP	ALBIA, ELISA	IPP, ELISA	ELISA, IIF	IPP	LIA, IPP	IPP	IPP	IPP	IPP
Ro	4	6	11	1	1	1	6	6	5	6	2	-	1	1	-	-	-	-	-
Ku	6	7	4	1	-	-	2	8	4	2	-	1	-	-	1	-	-	-	-
Jo-1	11	4	2	-	-	-	-	2	3	1	2	-	1	-	-	-	-	-	-
PL-7	1	1	-	2	-	-	-	1	2	-	-	-	-	-	-	-	-	-	-
PL-12	1	-	-	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-
KS	1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
U1RNP	6	2	-	-	-	-	6	2	2	-	-	-	-	1	-	-	-	-	1
Fibrillarin	6	8	2	1	1	-	2	1	2	1	-	1	1	-	1	-	-	-	-
La	5	4	3	2	-	-	2	2	3	1	1	-	-	-	1	1	-	-	1
PM-Scl	6	2	1	-	-	-	-	1	1	2	1	-	-	-	1	-	-	-	-
Topo	2	-	2	-	-	-	-	-	1	1	-	-	-	-	1	-	-	-	-
RNAPOLIII	-	1	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-
CENP-B	1	-	1	-	-	-	-	1	-	-	-	-	-	-	-	-	-	-	-
Th	1	-	-	-	-	-	1	-	-	-	-	-	-	1	-	-	-	-	-
Mi-2	-	1	-	-	-	-	-	1	1	1	1	1	-	-	3	-	-	-	-
NUP	-	-	-	-	-	-	-	-	1	-	-	-	-	-	-	2	-	-	-
SRP	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2	-	-
U5RNP	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	1	-
U2RNP	-	-	-	-	-	-	1	-	1	-	-	-	-	-	-	-	-	-	-

Numbers in bold denote that a single autoantibody specificity was detected. -, absence of autoantibody; ALBIA, addressable laser bead immunoassay; CENP, centromere protein; ELISA, enzyme-linked immunosorbent assay; IIF, indirect immunofluorescence; IPP, immunoprecipitation; LIA, line immunoassay; NUP, nucleoporins; RNAPOLIII, RNA polymerase III; SRP, signal recognition particle; TNT, transcription and translation assay; Topo, topoisomerase I.

ISSN: 1478-6362