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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study

Figure 1

Effects of IL-1 and IL-1 receptor antagonist (IL-1Ra) on the in situ zymography profile of degenerate and non-degenerate intervertebral discs (IVDs). The six graphs compare matrix degrading activity in the nucleus pulposus (NP) and annulus fibrosus (AF) for the three substrates in non-degenerate, moderately degenerate and severely degenerate IVDs and following treatement with IL-1 and IL-1Ra. The data are expressed in terms of absolute area of gel degraded (Y-axis = area degraded (maximum 10% in NP and 2.5% in AF)). Data are expressed as mean + standard error of the mean.

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