Figure 3

Migratory response of circulating progenitor cells (CPCs) to tumor necrosis factor (TNF)-α and vascular endothelial growth factor (VEGF). CPCs from ten patients and ten controls were cultured in angiogenic medium for 14 days, detached and placed in the upper chamber of a migration chamber. The lower chamber was filled with medium alone or with medium with either 50 ng/ml VEGF or 50 ng/ml TNF-α. Migration on VEGF and TNF-α was calculated as percentage of migration increase of CPCs compared to spontaneous migration on medium only. The line represents the mean.