Skip to main content

Advertisement

Table 1 Characteristics of systemic sclerosis patients with low, intermediate and high serum IL-15 levels

From: Serum IL-15 in patients with early systemic sclerosis: a potential novel marker of lung disease

Characteristic Low IL-15 level, <0.64 pg/ml (n = 33)   Intermediate IL-15 level, 0.64–0.88 pg/ml (n = 15)   High IL-15 level, >0.88 pg/ml (n = 13)  
Female/male 29/4 (88/12) 11/4 (73/27) 10/3 (77/23)
Age at onset (years) 52 (45–57) 48 (45–54) 57 (53–61)
Disease duration (months) 19 (13–28) 16 (11–25) 11 (8–21)
Clinical features       
   Skin score (points) 9 (4–14) 11 (4–17) 15 (8–21)
   Diffuse cutaneous systemic sclerosis/limited cutaneous systemic sclerosis 8/25 (24/76) 3/12 (20/80) 6/7 (46/54)
   Pitting scars or ulcer 9 (27) 6 (40) 3 (23)
   Telangiectasis 9 (27) 6 (40) 1 (8)
   Calcinosis 6 (18) 5 (33) 5 (38)
Organ involvement       
   Oesophagus 20 (61) 11 (73) 10 (77)
   Lung (radiological) 7 (21) 2 (13) 4 (31)
   Heart 5 (15) 4 (27) 4 (31)
   Kidney 1 (3) 1 (7) 0 (0)
   Muscle 1 (3) 2 (13) 1 (8)
   Joint 5 (15) 1 (7) 0 (0)
Lung function tests       
   Vital capacity (p%) 94 (85–103) 94 (84–105) 75 (66–89)*
   Diffusing capacity for carbon monoxide (p%) 84 (77–97) 71 (60–87) 70 (62–81)
Serological findings       
   Antinuclear antibodies 21 (64) 14 (93) 11 (85)
   Anti-scleroderma-70 antibodies 6 (18) 4 (27) 2 (15)
   Anticentromer antibodies 10 (30) 2 (13) 2 (15)
Laboratory findings       
   Erythrocyte sedimentation rate (mm/hour) 17 (10–27) 12 (8–22) 12 (6–18)
   C-reactive protein (mg/l) 0 (0–6) 0 (0–8) 1.6 (0–8.1)
   Orosomucoid (g/l) 0.8 (0.68–0.91) 0.86 (0.77–0.96) 0.85 (0.80–1.11)
   IgG (g/l) 10.9 (9.5–14.6) 9.5 (7.6–12.2) 12.6 (9.6–15.1)
  1. Data presented as the median (25th and 75th percentiles) or as n (%). Kruskal–Wallis analysis showed P < 0.05 for the vital capacity and diffusing capacity for carbon monoxide. *P < 0.05 for high IL-15 serum level versus low and intermediate IL-15 serum levels; P < 0.05 for high IL-15 serum level versus low IL-15 serum level; P = 0.057 for intermediate IL-15 serum level versus low IL-15 serum level.