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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Skewed distribution of proinflammatory CD4+CD28nullT cells in rheumatoid arthritis

Figure 3

CD4+CD28null T cells from peripheral blood and synovial fluid show human cytomegalovirus specificity. (upper panel) The functional capacity of CD4+CD28null T cells in peripheral blood (PB) and synovial fluid (SF) was investigated after stimulation of mononuclear cells from paired PB and SF from rheumatoid arthritis patients by plate-bound anti-CD3 antibodies. (lower panel) The reactivity of CD4+CD28null T cells in paired PB and SF to human cytomegalovirus (HCMV) antigens was analysed after stimulation by the pp65 or immediate early (IE) antigens.

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