Serum proteins and immunoglobulins in women with/without connective tissue disease and with/without silicone implants. Box plots: vertical lines identify the 10th and 90th percentiles, horizontal lines in boxes identify the 25th, 50th (median), and 75th percentiles, while 'outliers' are shown with open symbols. Ref. (filled columns), reference intervals; CTD+ and S-, Group 2 (74 women with connective tissue disease (CTD) but no silicone implants); CTD+ and S+, Group 1 (74 women with CTD and with silicone implants); CTD- and S-, Group 3 (14 women with no disease and no silicone implants); CTD- and S+, Group 4 (14 women with no disease but silicone implants). Alpha 1, α1-globulin; alpha 2, α2-globulin; beta, β-globulin; gamma, γ-globulin. NS, not significant; *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 by paired t test.