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Table 2 Characteristics of women with connective tissue disease and silicone implants in whom paraproteinemia was identified from Group 1

From: Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case–control study

Age (years)

Connective tissue disease

Silicone implant

Serum paraprotein (isotype)a

 

Type

Duration (years)

Type

Duration (years)

Exposure (years)

Ruptureb

 

48

UCTD

15.4

Silicone gel, saline

17.7

18.0

Yes

IgM(λ)

49

FMS/UCTD

15.2

Silicone gel (chin)

6.0

17.7

Yes

IgG(κ)

53

UCTD

6.2

Saline

3.5

3.5

Yes

IgG(λ)

55

Systemic sclerosis

12.1

Polyurethane

4.3

16.1

n/a

IgG(κ)

60

UCTD/FMS

3.9

Silicone gel

20.1

24.2

Yes

IgG(κ)

61

Dermatomyositis

4.2

Silicone gel

10.0

10.2

Yes

IgG(κ)

63

UCTD

16.1

Silicone gel

n/a

23.3

Yes

IgM(λ)

All: (55.6 ± 5.9)

 

10.4 ± 5.5

 

10.3 ± 7.1

16.1 ± 7.3

  
  1. Subjects are listed in increasing order of age. All subjects were White. FMS, fibromyalgia syndrome; UCTD, undifferentiated connective tissue disease; n/a, not available. aBased on protein electrophoresis, all paraprotein bands were considered weak (defined as <1 g/l). bImplant rupture was suspected by signs and symptoms in six cases and was documented at surgery in four cases.