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Table 2 Characteristics of women with connective tissue disease and silicone implants in whom paraproteinemia was identified from Group 1

From: Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case–control study

Age (years) Connective tissue disease Silicone implant Serum paraprotein (isotype)a
  Type Duration (years) Type Duration (years) Exposure (years) Ruptureb  
48 UCTD 15.4 Silicone gel, saline 17.7 18.0 Yes IgM(λ)
49 FMS/UCTD 15.2 Silicone gel (chin) 6.0 17.7 Yes IgG(κ)
53 UCTD 6.2 Saline 3.5 3.5 Yes IgG(λ)
55 Systemic sclerosis 12.1 Polyurethane 4.3 16.1 n/a IgG(κ)
60 UCTD/FMS 3.9 Silicone gel 20.1 24.2 Yes IgG(κ)
61 Dermatomyositis 4.2 Silicone gel 10.0 10.2 Yes IgG(κ)
63 UCTD 16.1 Silicone gel n/a 23.3 Yes IgM(λ)
All: (55.6 ± 5.9)   10.4 ± 5.5   10.3 ± 7.1 16.1 ± 7.3   
  1. Subjects are listed in increasing order of age. All subjects were White. FMS, fibromyalgia syndrome; UCTD, undifferentiated connective tissue disease; n/a, not available. aBased on protein electrophoresis, all paraprotein bands were considered weak (defined as <1 g/l). bImplant rupture was suspected by signs and symptoms in six cases and was documented at surgery in four cases.