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Table 4 Characteristics of women with connective tissue disease and silicone breast implants who were previously diagnosed with paraproteinemia (Group 6)

From: Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case–control study

Age (years) Connective tissue disease Silicone implant Serum paraprotein (concentration and isotype)a
  Type Duration (years) Type Duration (years) Exposure (years) Ruptureb  
43 UCTD/FMS 7.0 Silicone gel 14.2 17.1 Yes 6 g/l IgG(κ)
44 UCTD 12.8 Silicone gel 15.3 17.7 No 3 g/l IgG(λ), 3 g/l IgG(λ)
46 UCTD 7.1 Silicone gel 15.1 17.2 Yes 4 g/l IgG(κ), IgG(λ)
50 UCTD 4.0 Silicone gel/polyurethane 10.5 17.4 Yes 5 g/l IgM(κ)
50 UCTD 8.0 Silicone gel n/a 19.2 Yes 13 g/l IgG(κ), 6 g/l IgG(κ)
52 UCTD 4.6 Silicone gel 14.1 20.5 Yes 4 g/l IgG(κ)
54 UCTD 3.0 Silicone gel/saline 11.4 14.2 Yes 1 g/l IgG(κ)
55 UCTD/FMS 5.0 Silicone gel 21.0 30.0 Yes 7 g/l IgG(λ)
56 UCTD 10.4 Silicone gel 15.1 23.3 No 9 g/l IgG(κ)
58 UCTD 9.3 Silicone gel 13.5 18.1 Yes 22 g/l IgG(λ)
All: 50.8 ± 5.2   7.1 ± 3.1   14.5 ± 3.0 19.5 ± 4.4   
  1. Subjects are listed in increasing order of age. All subjects were White. FMS, fibromyalgia syndrome; UCTD, undifferentiated connective tissue disease; n/a, not available. aWeak paraprotein bands (defined as <1 g/l) are shown without specifying their concentration; all others are shown by concentrations estimated from protein electrophoresis. bImplant rupture was suspected by signs and symptoms in eight cases and was documented at surgery in five cases.