Typical radiographic images obtained on day 28, showing differences in paws. The groups were control rats, vehicle-treated rats with collagen-induced arthritis (CIA), and rats with CIA treated with anti-IL-23 antibody on day 28. (a, c, e) Frontal views; (b, d, f) lateral views. (a, b) Control rats. (c, d) Rats with CIA treated with vehicle. (e, f) Rats with CIA treated with anti-IL-23 antibody (3.0 μg) from day 14. Note that rats wth CIA treated with vehicle showed radiographic changes characterized by bone erosion and joint space narrowing.