Effect of dehydroxymethylepoxyquinomicin on inflammation and bone destruction in collagen-induced mouse arthritis. (a) Increase (%) of the sum of the thickness of the right and left hind paws in each mouse during day -4 and day 10. Horizontal bars represent the mean. DHMEQ, dehydroxymethylepoxyquinomicin. (b) Radiographic scores of the ankle joints were determined as described in Materials and methods, and were normalized to the normal mice. Values are expressed as the mean ± standard deviation, and represent data obtained by three independent investigators. Data were compared by Student's t test.