A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity

Table 4 Logistic regression analysis of rs729749 in cases stratified for autoantibody status

Status	Subgroup	Genotype CT versus CC			Genotype TT versus CC
		OR	95% CI	P	OR	95% CI	P
All	All	0.80	0.66 to 0.97	0.02	1.04	0.67 to 1.62	0.86
	Women	0.94	0.75 to 1.17	0.56	1.01	0.60 to 1.71	0.97
	Men	0.50	0.35 to 0.73	0.0002	1.20	0.52 to 2.81	0.67
RF positive	All	0.85	0.69 to 1.04	0.12	0.92	0.56 to 1.53	0.76
	Women	0.96	0.75 to 1.23	0.74	1.03	0.58 to 1.84	0.92
	Men	0.59	0.39 to 0.88	0.009	0.74	0.26 to 2.12	0.58
RF negative	All	0.70	0.54 to 0.90	0.006	1.24	0.71 to 2.14	0.45
	Women	0.88	0.65 to 1.18	0.39	0.94	0.47 to 1.90	0.87
	Men	0.34	0.20 to 0.60	0.0001	2.03	0.88 to 5.29	0.15
Anti-CCP positive	All	0.86	0.70 to 1.07	0.17	1.01	0.61 to 1.71	0.98
	Women	1.02	0.80 to 1.31	0.88	1.12	0.63 to 2.00	0.70
	Men	0.54	0.36 to 0.83	0.003	0.79	0.28 to 2.24	0.65
Anti-CCP negative	All	0.69	0.54 to 0.89	0.004	1.07	0.62 to 1.84	0.82
	Women	0.82	0.61 to 1.10	0.19	0.86	0.43 to 1.73	0.67
	Men	0.4	0.2 to 0.7	0.0004	1.8	0.7 to 4.6	0.26

CCP, cyclic citrullinated peptide; CI, confidence interval; OR, odds ratio; RF, rheumatoid factor.

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